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Oral melanotic macules can appear at any age and in any gender, however, it is more commonly seen in dark-skinned middle-aged females

Rodrigo LC, Andrea BZ, Stefania ES, et al

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Powders quickly lose their efficacy when stored in hot or damp places

Moreover, no signs of inflammation were observed in nasal mucosa of co-modified-BM-loaded PLGA-treated mice, suggesting a safe and non-invasive strategy for intranasal delivery 127

We investigated whether this mechanism contributes to the efficacy of the Roux-en-Y gastric bypass (RYGB) by assessing the effect of oligofructose-enriched inulin (inulin) vs